Local allergic rhinitis – a narrative review

F. Manole, N. Bayar Muluk, O. Oğuz, S. Ulusoy, G.K. Scadding, E. Prokopakis, L. Kalogjera, P. Rombaux, C. Cingi

Department of ENT, Faculty of Medicine, University of Oradea, Oradea, Romania. nbayarmuluk@yahoo.com

---

• Rhinology

This narrative review aims to provide an up-to-date definition of local allergic rhinitis (LAR), its classification, mechanisms, comorbidities, recommendations for diagnosis and treatment, and define needs in this area. Both ‘PubMed’ and ‘Science Direct’ literature was reviewed systematically, and a manual search for studies not previously encountered in the databases was also carried out. Published studies were identified in PubMed covering the period from 1947 to 2022. The following keyword search strategy was used: (local allergic rhinitis* OR entopy* OR local Immunoglobulin E * OR nasal specific Immunoglobulin E). LAR involves Type 2 nasal inflammation with local IgE and cannot be diagnosed by systemic methods, such as skin prick or blood IgE tests. A nasal allergen challenge is necessary for diagnosis. LAR can respond to usual AR treatments, including allergen specific immunotherapy (AIT). LAR is a novel entity that requires additional investigation in terms of prevalence, proper diagnosis, treatment, and prognosis. The target outcomes and possible benefits of this review are to achieve a consensus for the study and diagnosis of LAR and increase interest in this area.

Free PDF Download