Eur Rev Med Pharmacol Sci 2024; 28 (10): 3548-3555
DOI: 10.26355/eurrev_202405_36291

Novel quinoxaline compound against extended-spectrum beta-lactamases producing bacteria

K. Alkuwaity, J.A. Mokhtar, T. Abujamel, D. Attallah, T.A. Altorki, M. Alsieni, M.A. Bazuhair, N.R. Helmi, H. AbdulMajed, N.A. Juma, H. Abdullah, M.W. Al-Rabia, K. Ibrahem, A. Alfadil

Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. aegmusa@kau.edu.sa


OBJECTIVE: Extended-spectrum beta-lactamases (ESBLs) targeting beta-lactam antibiotics pose a major healthcare challenge. Carbapenems are known to be less impacted. However, the emergence of carbapenem-resistant strains can add further complexity to this existing challenge. With slow drug discovery and rapid resistance, repurposing existing drugs is crucial. This research study aims to provide insight into the antimicrobial effectiveness of 3-hydrazinoquinoxaline-2-thiol against diverse clinical ESBL-producing isolates.

MATERIALS AND METHODS: The broth microdilution assay was conducted on a total of sixty-nine clinical ESBL-producing isolates to assess the minimum inhibitory concentrations (MICs) of 3-hydrazinoquinoxaline-2-thiol. The assay was conducted in triplicate, and the average MIC values were calculated.

RESULTS: The most repeatedly observed MIC was 64 µg/ml (37.7%), followed by 256 µg/ml (23.2%) and 128 µg/ml (17.4%). Other MICs: 32 µg/ml (11.6%), 16 µg/ml (7.2%), 4-8 µg/ml (1.4%).

CONCLUSIONS: This study demonstrated an effect of 3-hydrazinoquinoxaline-2-thiol on various ESBL-producing strains in vitro, indicating its promising therapeutic potential. To comprehensively understand the drug, rigorous testing, including pharmacokinetics, resistance assays, safety assessments, and exploration of potential synergies with other antibiotics against ESBL-producing organisms, is crucial.

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K. Alkuwaity, J.A. Mokhtar, T. Abujamel, D. Attallah, T.A. Altorki, M. Alsieni, M.A. Bazuhair, N.R. Helmi, H. AbdulMajed, N.A. Juma, H. Abdullah, M.W. Al-Rabia, K. Ibrahem, A. Alfadil
Novel quinoxaline compound against extended-spectrum beta-lactamases producing bacteria

Eur Rev Med Pharmacol Sci
Year: 2024
Vol. 28 - N. 10
Pages: 3548-3555
DOI: 10.26355/eurrev_202405_36291