The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced astrocyte activation in striatal area induced by MPTP. The results show that HPE has neuromodulating effect against MPTP induced Parkinson’s disease in mice.
Corresponding Author: Muthukumar Sabesan, MD; e-mail: email@example.comFree PDF Download
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M. Mohanasundari, M. Sabesan
Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson’s disease in mic
Eur Rev Med Pharmacol Sci
Vol. 11 - N. 1