Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice

A.M. Saleem, M. Taufik Hidayat, A.M.M. Jais, S. Fakurazi, M.A.M. Moklas, M.R. Sulaiman, Z. Amom, R. Basir

Department of Human Anatomy and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, UPM Serdang, Selangor, Malaysia. taufik@medic.upm.edu.my

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• Pharmacology

BACKGROUND: In our previous study, the aqueous extract of Channa striatus (family: Channidae) fillet (AECSF) showed an antidepressant-like effect in mice. However, the mechanism of the antidepressant-like effect is unknown.

AIM: The objective of this study was to explore the involvement of monoamines in the antidepressant-like effect of AECSF in mice.

MATERIALS AND METHODS: AECSF was prepared by steaming the fillets of C. striatus. The male ICR mice were pretreated with various monoaminergic antagonists viz., p-chlorophenylalanine (100 mg/kg, i.p.), prazosin (1 mg/kg, i.p.) and yohimbine (1 mg/kg, i.p.), SCH23390 (0.05 mg/kg, s.c.) and sulpiride (50 mg/kg, i.p.) followed by treatment with AECSF and tested in tail suspension test (TST). Two-way ANOVA with Tukey test were used at p < 0.05 for significance.

RESULTS: The pretreatments with p-chlorophenylalanine, prazosin and yohimbine, but not with SCH23390 and sulpiride, were able to reverse the antidepressant-like effect of AECSF in TST.

CONCLUSIONS: The antidepressant-like effect of AECSF may be mediated through the serotonergic and noradrenergic systems and not through the dopaminergic system.

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