Analysis report for osteosarcoma expression profile

C. Li, C. Zhan, Y. Chen, Q. Fu, X.D. Zhu, D.W. He, M. Li, Z.W. Wang

Department of Orthopedics, Changhai  Hospital, Second Military Medical University, Shanghai, China. mlzhwwang@hotmail.com

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• Orthopedics

BACKGROUND: Osteosarcoma is a kind of highly malignant primary bone tumor which most common in the teenage, and holds strong aggressive, earlier organs metastases mainly to lung, prone to postoperative recur. Therefore for osteosarcoma, invasion and transfer mechanism and related factors’ interaction remains to be a key research subject.

AIM: We aim to find biological molecules marker can be used for osteosarcoma diagnosis through contrast of osteosarcoma sample and normal tissue samples.

MATERIALS AND METHODS: This analysis using human osteosarcoma expression profile data and three lesions normal tissue samples (liver, kidneys, lymph) expression data and compare them, and find significant specifically expressed genes, according to their function.

RESULTS: Research shows that the cancer cell proliferation, invasion, transfer and recurrent process involve many factors interaction, of which angiogenesis is the necessary condition of tumor growth, transfer and the recurrence.

CONCLUSIONS: Now the most important positive regulatory factor of angiogenesis is VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor). Both of them are with a wide variety and close relationship of tumor angiogenesis and progress.

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