BACKGROUND: Osteoarthritis (OA), also referred to as degenerative joint disease or wear-and-tear arthritis, is caused by the breakdown of joint cartilage. Rheumatoid arthritis (RA) is a chronic, inflammatory type of arthritis. RA is also classified as a kind of autoimmune disease.
AIM: To find the important genes in RA and OA.
MATERIALS AND METHODS: Comprehensively compared 3 datasets of RA with 2 datasets of OA, 98 genes were sifted. We explored protein-protein associations processed for the 98 genes by mining famous gene/protein interaction/association database.
RESULTS: We found most of those genes appear to play a key role in the anti-inflammatory and immunosuppressive effects.
CONCLUSIONS: Our research would play a useful role in the diagnosis and treatment of OA and RA.Free PDF Download
To cite this article
Q. Zhang, B. Cheng, C.-X. Yang, H.-A. Ge
Interaction relationships of osteoarthritis and rheumatoid arthritis related genes
Eur Rev Med Pharmacol Sci
Vol. 18 - N. 2