The evaluation of Lugol’s iodine solution staining combined with endoscope for diagnosis of non-erosive reflux disease in clinic

H. Zhao, L. Xue, J. Liu, H.-y. Zhang, D. Zhang, X.-h. Song, Y.-x. He, T. Yang, C.-q. Li, Y.-q. Li

Department of Gastroenteroloy, Qilu Hospital, Shandong University, Jinan, Shandong Province, China. liyanqing@sdu.edu.cn

 

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• Gastroenterology

AIM: To evaluate the value of Lugol’s iodine solution staining combined with endoscope on the diagnosis of non-erosive reflux disease (NERD).

PATIENTS AND METHODS: A total of 96 gastroesophageal reflux disease patients were selected to participate in this study. The patients were stained on esophageal mucosa by Lugol’s iodine solution and examined at routine endoscopy. The shallow staining and/or non-staining group patients were treated with esomeprazole and mosapride citrate, and then the changes in Lugol’s iodine staining, Gerd Q (Gerd questionnaire) scoring and histological characters of esophageal mucosa were recorded before and after treatment.

RESULTS: As the results, a total of 68 patients were diagnosed as NERD, and 36 of 68 patients were observed with uniform staining and 32 of 68 patients were observed with shallow staining and/or non-staining. After 4 weeks for treatment, 28 of 32 patients with shallow staining and/or non-staining became uniform staining and 4 of 32 patients were still with shallow staining and/or non-staining. Before and after treatment, the Gerd Q scoring of uniform staining groups and shallow staining and/or non-staining groups all had a significant difference (p < 0.05). Compared to the routine endoscopy, the detection rate of abnormal esophageal mucosa was significantly increased by Lugol’s iodine solution staining combined with endoscope.

CONCLUSIONS: Lugol’s iodine solution staining combined with routine endoscopy, Gerd Q scoring and histomorphology can be used to evaluate the diagnosis and therapeutic effect of NERD.

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