Eur Rev Med Pharmacol Sci 2009; 13 (2): 117-128

Bone health as a primary target in the pediatric age

P. Caradonna, D. Rigante*

Department of Internal Medicine, *Department of Pediatric Sciences, Catholic University of the Sacred Heart, Rome (Italy)

Bone tissue is constantly renewed during childhood and adolescence to assure skeleton growth both in size and mineral density: up to 90 percent of peak bone mass is acquired by age 18 in girls and age 20 in boys, which makes youth the best time to “invest” in bone health. The reduction in bone mineral density leading to compromised strength and microarchitecture of bone tissue can favour the occurrence of fragility fractures in the pediatric age. Assessing the normality of bone density measurements in childhood by current methods is hampered by the lack of normative control data. The understanding of factors useful for maximizing peak bone mass, as well as the knowledge of diagnostic tools and therapeutic strategies for managing a state of reduced bone mineral density are crucial to prevent fractures throughout lifetime.

Corresponding Author: Donato Rigante, MD; e-mail:

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To cite this article

P. Caradonna, D. Rigante*
Bone health as a primary target in the pediatric age

Eur Rev Med Pharmacol Sci
Year: 2009
Vol. 13 - N. 2
Pages: 117-128