Integrated bioinformatics analyses identify dysregulated miRNAs in lung cancer

J. Wang, Y.-C. Zhao, Y.-D. Lu, C.-P. Ma

Department of Thoracic Surgery, Zhangjiagang First People’s Hospital, Zhangjiagang, Jiangsu, China. zjgmcp@sina.com

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• Oncology

BACKGROUND: Lung cancer is the most common cause of cancer-related death worldwide. MicroRNAs (miRNAs) play important roles in various biological processes, including cell development, proliferation, differentiation and apoptosis.

MATERIALS AND METHODS: In the current study, using miRNA expression profiles from the Gene Expression Omnibus (GEO) database, we used three independent tests: Wilcox test, t-test and Fisher’s exact test to investigate miRNA’s involvement in lung carcinogenesis.

RESULTS: Ten differentially expressed miRNAs were identified. Among them, miR-675 drew specific attention. Ingenuity pathway analysis of its target genes revealed its impact on cell death and cell cycle. It is possible that miR-675 contributes to the pathogenesis of lung cancer through its down regulation of the tumor suppressor gene RB1.

CONCLUSIONS: Our results suggest miR-675 may serve as a potential therapeutic target of lung cancer.

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