Renal involvement is a common manifestation in course of systemic lupus erythematous (SLE) and may occur at any time.
In SLE nephritis, the pattern of glomerular injury is primarily related to the formation of the immune deposits in situ, due major to antidouble-stranded DNA (anti-dsDNA) antibodies and anti- C1q. Immune complexes deposits can induce the inflammatory response by activation of adhesion molecules on endothelium, resulting in the recruitment of pro inflammatory leukocytes. Activated and damaged glomerular cells, infiltrating macrophages, B and T cells produced cytokines that play a pivotal role as inflammatory mediators to extend renal injury. In serum of SLE patients, the concentrations of IL-6, IL-17, IL-12, INF-gamma, IL-18, IL-10 and TNF-alpha are higher than healthy people and this increase correlate with disease activity. It is well established possible correlation between urinary cytokines levels (IL-6, IL-10, INF-γ and TGF-beta) and disease activity. In fact, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) correlate with cytokines over-expression, in particular IL-17, IL-10, TNF-alpha and the axis INF-gamma/IL-12.
Recent studies are promising about proteinuria reduction and improving renal function through cytokine blockade therapy.
Corresponding Author: Antonietta Gigante, MD; e-mail: firstname.lastname@example.orgFree PDF Download
To cite this article
A. Gigante, M.L. Gasperini, A. Afeltra*, B. Barbano**, D. Margiotta*, R. Cianci**, I. De Francesco**, A. Amoroso
Cytokines expression in SLE nephritis
Eur Rev Med Pharmacol Sci
Vol. 15 - N. 1