Background: Jasmonates are plant stress hormones. These small hydrophobic compounds exhibit anti-cancer activities, in vitro and in vivo, against cancer cells of various histological origins. Moreover, they show a selective activity against transformed cells and affect drug-resistant cells as well.
Aim: The aim of this study was to evaluate the activity of a powerful jasmonate derivative, that is methyl jasmonate.
Material and Methods: Methyl jasmonate was applied topically on cancerous and pre-cancerous skin lesions from eight patients.
Results: Methyl jasmonate did not cause any meaningful local or systemic side effects. Three patients exhibited positive responses. Two patients had complete recovery and one had a recurrence of the lesion three months post treatment.
Conclusions: Methyl jasmonate is a potentially promising novel topical treatment for prcancerous and cancerous skin lesions. Methyl jasmonate should be evaluated in a larger series of patients.
Corresponding Author: Tommaso Iannitti, MD; e-mail: Tommaso.Iannitti@gcal.ac.ukFree PDF Download
To cite this article
B. Palmieri 1, T. Iannitti 2,3, S. Capone 1,3, E. Flescher 4
A preliminary study of the local treatment of preneoplastic and malignant skin lesions using methyl jasmonate
Eur Rev Med Pharmacol Sci
Vol. 15 - N. 3