Effect of beta-Glucan, Inositol and digestive enzymes in GI symptoms of patients with IBS

C. Ciacci, F. Franceschi*, F. Purchiaroni*, P. Capone**, F. Buccelletti*, P. Iacomini*, A. Ranaudo**, P. Andreozzi**, P. Tondi#, N. Gentiloni Silveri*, A. Gasbarrini°, G. Gasbarrini§

Gastroenterology Unit, University of Salerno (Italy) *Emergency Department, School of Medicine, Catholic University of the Sacred Heart, Rome (Italy) **Department of Clinical and Experimental Medicine, University Federico II of Naples (Italy) #Department of Medical Angiology, and °Department of Internal Medicine and Gastroenterology, School of Medicine, Catholic University of the Sacred Heart, Rome (Italy) §Fondazione Ricerca in Medicina, Bologna (Italy)

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• Gastroenterology

Background: Irritable bowel syndrome (IBS) is a very common functional gastrointestinal (GI). Diagnosis of IBS is based on the fulfilment of the Rome III criteria. Common GI symptoms are lower abdominal pain, bloating and disturbed defecation, such as urgent diarrhoea and/or episodes of chronic constipation. Many agents have been employed in the management of IBS, although only few have been demonstrated to show a relevant efficacy.

Aim: To evaluate the effectiveness of the administration of a mixture of beta-glucan, inositol and digestive enzymes (Biointol®) in improving GI symptoms in patients affected by IBS.

Patients and Methods: 50 IBS patients (20 males, 30 females; mean age 51±19) were treated with Biointol® (group A) while another group consisting of 40 IBS patients (15 males, 25 females; mean age 50±18) did not receive any therapy (group B).

Results: Biointol® administration improved significantly bloating, flatulence and abdominal pain, with a slight increasing of urgency for bowel movements. On the contrary, Biointol® did not show any significant effect on the other IBS symptoms.

Conclusions: Currently, only few agents used in the management of IBS have been proven to be effective. Biointol® administration has shown to improve some IBS symptoms, such as bloating, flatulence and abdominal pain, all connected to the presence of gas inside the intestinal lumen.

Corresponding Author: Giovanni Gasbarrini, MD; e-mail: studiogasbarrini@gasbarrini.it

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