LncRNA GHET1 predicts a poor prognosis of the patients with non-small cell lung cancer

Q.-M. Shen, H.-Y. Wang, S. Xu

China Medical University, Shenyang, China. drxushun@sina.com

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• Oncology

OBJECTIVE: Long non-coding RNAs (LcRNAs) is related to lung cancer progression. This study aimed at exploring lncRNA GHET1 in non-small cell lung cancer (NSCLC).

PATIENTS AND METHODS: RT-PCR was used to detect lncRNA GHET1 expression in lung cancer specimen and cancer-adjacent areas. Kaplan-Meier assay was applied to investigate the prognosis of the patients with lung cancer.

RESULTS: The expression of lncRNA GHET1 in lung cancer specimen was significantly higher than that in the cancer-adjacent tissues, which was related to the tumor size, differentiation degree of tumor cells, and lymph node metastasis of clinical specimens. Moreover, lncRNA GHET1 predicted a poor prognosis for the patients with lung cancer.

CONCLUSIONS: LncRNA GHET1 might be a biomarker and molecular target of NSCLC, providing a potential therapeutic target of NSCLC.

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