Eur Rev Med Pharmacol Sci 2018; 22 (14): 4589-4597

DOI: 10.26355/eurrev_201807_15516

Is fatigue a cause of work disability in systemic lupus erythematosus? Results from a systematic literature review

F. Basta, D.P.E. Margiotta, M. Vadacca, A. Vernuccio, C. Mazzuca, A. Picchianti Diamanti, A. Afeltra

ImmunoRheumatology Unit, Policlinico Universitario Campus Biomedico, Rome, Italy. d.margiotta@unicampus.it


OBJECTIVE: Fatigue affects the almost totality of Systemic Lupus Erythematous (SLE) patients impairing physical function and leading to a strong reduction of health-related quality of life (HRQoL). Similarly, SLE patients have an increased rate of work loss and work limitations. The aim of our paper was to systematically assess the relationship between fatigue and work disability in SLE.

MATERIALS AND METHODS: We performed a systematic review using the terms “fatigue” and “employment”, “work disability”, “work impairment”, “presenteeism” and “absenteeism.”

RESULTS: 19 studies were identified. Fatigue was involved in the development of work loss. In employed patients, fatigue led to impairment of work productivity and presenteeism with a parallel increase of both direct and indirect health costs. Fatigue also affected parenting and household productivity.

CONCLUSIONS: An adequate control of fatigue could improve physical and work performance in SLE patients thus reducing rates of work loss.

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To cite this article

F. Basta, D.P.E. Margiotta, M. Vadacca, A. Vernuccio, C. Mazzuca, A. Picchianti Diamanti, A. Afeltra
Is fatigue a cause of work disability in systemic lupus erythematosus? Results from a systematic literature review

Eur Rev Med Pharmacol Sci
Year: 2018
Vol. 22 - N. 14
Pages: 4589-4597
DOI: 10.26355/eurrev_201807_15516