Abstract. – The role of cytokines in systemic lupus erythematosus (SLE) glomerulonephritis is extremely complex. Proinflammatory molecules, such as TNF, IL-6, IL-1 and IL-18 are upregulated, as are both Th1 and Th2 cytokines, with different implications: the local effects may be different from the systemic immunoregulatory ones. Excessive T helper cell function is a hallmark of SLE and abnormalities of Th citokine profiles have been implicated in loss of immune tolerance, increased antogenic load, defective B cell suppression and a variety of clinical manifestations. For some cytokines, TNF and IL-18 in particular, the local proinflammatory ones may be more relevant to the disease.
Corresponding Author: Antonietta Gigante, MD; e-mail: email@example.comFree PDF Download
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
To cite this article
A. Gigante, D. Amoroso, F. Ferri, C. Gianni, G. Coppolino*, A. Papa, A. Amoroso
Systemic lupus erythematosus and renal involvement: which role of citokines expression?
Eur Rev Med Pharmacol Sci
Vol. 10 - N. 5