Eur Rev Med Pharmacol Sci 2020; 24 (12): 7131-7137

DOI: 10.26355/eurrev_202006_21707

Endocan and advanced oxidation protein products in adult population with hypertension

A. Klisic, N. Kavaric, S. Vujcic, V. Spasojevic-Kalimanovska, A. Ninic, J. Kotur-Stevuljevic

Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro. aleksandranklisic@gmail.com


OBJECTIVE: Hypertension is closely related to oxidative stress and inflammation. Endocan is a new inflammation marker whose role is not completely elucidated in hypertension. The aim of this study was to explore the association between endocan and several oxidative stress markers [i.e., advanced oxidation protein products (AOPP), total protein sulfhydryl (SH-) groups and prooxidant-antioxidant balance (PAB)] in adult population with hypertension.

PATIENTS AND METHODS: A total of 90 patients with hypertension were compared with 44 controls. Blood pressure, anthropometric and biochemical parameters were measured. Associations of clinical data with hypertension were tested with univariable and multivariable logistic ordinal regression analysis.

RESULTS: Endocan and AOPP were significantly higher in hypertensive patients than in the controls (p=0.006 and p=0.046, respectively). In the multivariable logistic regression analysis, AOPP and endocan kept their independent positive associations with hypertension. As AOPP rose by 1 ╬╝mol/L and endocan rose by 1 pg/mL, the probability for hypertension presence rose by 4.2% and 32.2%, respectively and 39.9% of variation in hypertension could be explained with the Model. The area under the Receiver Operating Characteristic curve [(AUC) for AOPP=0.638 (0.550-0.719), p=0.01 and for endocan=0.679 (0.593-0.757), p<0.001] demonstrated sufficient clinical accuracy towards hypertension. On the contrary, the Model showed very good clinical accuracy [AUC= 0.825 (0.749-0.900), p<0.001].

CONCLUSIONS: Endocan and AOPP are independently correlated with hypertension in adult population and these tested markers together could be reliable parameters to discriminate patients with hypertension from normotensive ones.

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A. Klisic, N. Kavaric, S. Vujcic, V. Spasojevic-Kalimanovska, A. Ninic, J. Kotur-Stevuljevic
Endocan and advanced oxidation protein products in adult population with hypertension

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 12
Pages: 7131-7137
DOI: 10.26355/eurrev_202006_21707