Eur Rev Med Pharmacol Sci 2020; 24 (23): 12500-12509

DOI: 10.26355/eurrev_202012_24046

Could glutathione depletion be the Trojan horse of COVID-19 mortality?

A. Khanfar, B. Al Qaroot

Special Surgery Department, University of Jordan, Amman, Jordan. a.khanfar@ju.edu.jo


OBJECTIVE: Since the emergence of coronavirus disease (COVID-19), the death toll has been increasing daily. Many risk factors are associated with a high mortality rate in COVID-19. Establishment of a common pathway among these risk factors could improve our understanding of COVID-19 severity and mortality. This review aims at establishing this common pathway and its possible effect on COVID-19 mortality.

MATERIALS AND METHODS: The current review was executed in five consecutive stages starting from determining the risk factors of COVID-19 mortality and trying to find a common pathway among them depending on the available literature. This was followed by proposing a mechanism explaining how this common pathway could increase the mortality. Finally, its potential role in managing COVID-19 was proposed.

RESULTS: This review identified this common pathway to be a low baseline of reduced glutathione (i.e., GSH) level. In particular, this review provided an in-depth discussion regarding the pathophysiology by which COVID-19 leads to GSH depletion, tissue damage, and acute respiratory distress syndrome. In addition, the current review demonstrated how GSH depletion could result in failure of the immune system and rendering the end organs vulnerable to damage from the oxidative stress.

CONCLUSIONS: This preclinical study shows that GSH depletion may have a central role in COVID-19 mortality and pathophysiology. Therefore, elevating the GSH level in tissues may decrease the severity and mortality rates of COVID-19.

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To cite this article

A. Khanfar, B. Al Qaroot
Could glutathione depletion be the Trojan horse of COVID-19 mortality?

Eur Rev Med Pharmacol Sci
Year: 2020
Vol. 24 - N. 23
Pages: 12500-12509
DOI: 10.26355/eurrev_202012_24046