Eur Rev Med Pharmacol Sci 2021; 25 (3): 1680-1683

DOI: 10.26355/eurrev_202102_24879

Splenoportal-mesenteric axis thrombosis and splenic artery occlusion as initial presentations of COVID-19 disease

S. Vidali, D. Morosetti, A.V. Granai, J.M. Legramante, O.C. Buonomo, R. Argirò

Interventional Radiology Unit, Department of Biomedicine and Prevention, University Hospital Policlinico Tor Vergata, Rome Italy. renato.argiro@gmail.com


OBJECTIVE: Although pulmonary involvement represents the primary and most characteristic presentation of Sars-Cov-2 infection, due to its innate tropism for endothelium, it is also associated with systemic pro-coagulative changes and thromboses. This paper describes a COVID-19 atypical presentation with massive thrombotic occlusion of the splenoportal-mesenteric axis and the splenic artery in the absence of clinical or radiological manifestation of pulmonary involvement.

PATIENTS AND METHODS: Female patient, with no history of disease, trauma or fever in the last 30 days, was admitted to ER for persistent left subcostal pain. Laboratory exams, including inflammation, coagulation markers and Sars-CoV-2 serology, were requested. Whole-body CT with contrast media injection was performed.

RESULTS: Laboratory exams showed elevated reactive C-protein, bilirubin, γ-GT and D-dimer. Whole-body CT showed: splenic artery occlusion, thrombosis of splenic, mesenteric and portal veins with portal intra-hepatic branches ectasia, juxta-hilar portal cavernomatosis of probable acute onset (absence of signs of chronic hepatopathy and of varices), a hypodense area in the spleen indicating ischemic parenchymal suffering. The patient resulted positive for Sars-CoV-2 IgG, thus in the absence of typical clinics or pulmonary parenchymal abnormality at chest CT.

CONCLUSIONS: A case of acute venous thrombosis and arterial occlusion as primary manifestations of COVID-19.

 

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S. Vidali, D. Morosetti, A.V. Granai, J.M. Legramante, O.C. Buonomo, R. Argirò
Splenoportal-mesenteric axis thrombosis and splenic artery occlusion as initial presentations of COVID-19 disease

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 3
Pages: 1680-1683
DOI: 10.26355/eurrev_202102_24879