Eur Rev Med Pharmacol Sci 2021; 25 (23): 7425-7439

DOI: 10.26355/eurrev_202112_27440

Cardioprotective and nephroprotective effects of Quercetin against different toxic agents

A.F. Alasmari

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. afalasmari@ksu.edu.sa


Quercetin (Qct) is a flavonoid that belongs to the group of the most bioactive polyphenolic compounds. It is abundantly found in our diet, and it has many beneficial effects on human health because of its potent antioxidant properties. Qct has shown cardioprotective effects against doxorubicin, cyclophosphamide, daunorubicin, and lindane and nephroprotective effects against methotrexate, doxorubicin, gentamicin, valproic acid, cadmium, potassium dichromate, fluoride, mercury chloride, 2,3,7,8-tetrachlorodibenzo-p-dioxin, titanium dioxide nanoparticles, and gold nanoparticles. In the current review, we discussed the molecular and biochemical mechanisms involved in the cardio- and nephroprotective effects of Qct. The main purpose of this review was to identify the cardio- and the nephroprotective mechanisms of Qct against several drugs and chemicals to encourage further studies to investigate the potential protective effect of Qct.

Free PDF Download

To cite this article

A.F. Alasmari
Cardioprotective and nephroprotective effects of Quercetin against different toxic agents

Eur Rev Med Pharmacol Sci
Year: 2021
Vol. 25 - N. 23
Pages: 7425-7439
DOI: 10.26355/eurrev_202112_27440