Eur Rev Med Pharmacol Sci 2022; 26 (9): 3320-3324

DOI: 10.26355/eurrev_202205_28751

Efficacy of omalizumab in an atopic young adult with asthma and eosinophilic chronic rhinosinusitis with nasal polyps

G.L. Fadda, A. Galizia, L. Maugeri, R.F. Canevari, E. Crosetti, G. Cavallo

Department of Otolaryngology, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy. dott.fadda@gmail.com


OBJECTIVE: Chronic rhinosinusitis (CRS) presents a multifactorial etiology due to interactions between the immune host system and external agents. It can be classified into two phenotypes based on the presence or absence of polypoid neoformation (respectively CRSwNP and CRSsNP). According to EPOS2020, CRS is now classified into two endotypes, eosinophilic (ECRS) and non-eosinophilic (non-ECRS), based on eosinophil tissue count (more than 10 eosinophils per High Power Field, HPF).

CASE PRESENTATION: We present the case of a 31-year-old man affected by recalcitrant ECRSwNP and asthma.

RESULTS: He was treated with a combination of omalizumab and endoscopic sinus surgery. This combination led to a reduction in blood eosinophils, modified Lund-Kennedy endoscopic score, Lund-Mackay score, and Sino-Nasal Outcome Test (SNOT-22), almost 6 months after surgery.

CONCLUSIONS: In this clinical case, omalizumab regulated nasal symptoms for more than a year and with good control of the recalcitrant pattern when combined with ESS.

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G.L. Fadda, A. Galizia, L. Maugeri, R.F. Canevari, E. Crosetti, G. Cavallo
Efficacy of omalizumab in an atopic young adult with asthma and eosinophilic chronic rhinosinusitis with nasal polyps

Eur Rev Med Pharmacol Sci
Year: 2022
Vol. 26 - N. 9
Pages: 3320-3324
DOI: 10.26355/eurrev_202205_28751